The Fetal Institute


The Fetal Institute provides patients with the latest and most advanced resources in the field of Maternal-Fetal Medicine and Fetal Therapy. This includes high-resolution ultrasound imaging, non-invasive serum screening and prenatal testing (NIPT), as well as comprehensive invasive prenatal diagnostic and therapeutic techniques. Fundamental to the philosophy of the Institute, all diagnostic and therapeutic options are performed using either a non-invasive or a minimally invasive approach, which results in better pregnancy outcomes.
Founded by Dr. Ruben Quintero and Dr. Eftichia Kontopoulos, The Fetal Institute serves as a resource to all Obstetricians and Maternal-Fetal Medicine specialists. The Fetal Institute is a national and international referral center for the assessment and management of complicated pregnancies.


Dr. Ruben Quintero

Graduate from the Central University of Venezuela Luis Razetti School of Medicine. He did his residency in Obstetrics and Gynecology and Maternal-Fetal Medicine fellowship at Yale University. He is internationally known for his pioneering work in Fetal Therapy.
Using the principle of limiting fetal intervention to minimal-invasiveness, Dr. Quintero developed all of the necessary tools and instruments, surgical techniques and disease classifications that guide the treatment of many fetal conditions today.
Dr. Quintero has over 20 years of experience in the management of complicated pregnancies and has performed more than 1000 fetal surgeries.
Dr. Quintero has had a productive academic career, including the publication of the Quintero Staging System which is used in the assessment of patients affected with Twin-Twin Transfusion Syndrome. He is the editor of the first book on Twin-Transfusion syndrome, as well as the book on Diagnostic and Operative Fetoscopy.

Dr. Quintero has had hundreds of international presentations and has been featured in the media, including The New York Times, Washington Post, Der Spiegel, El Pais, ABC news, CBS news, Good Morning America and other media services.
Dr. Quintero has trained fetal surgeons around the world, including South America, Australia and Europe.
Dr. Quintero is an honorary member of the Venezuelan Ob/Gyn Society, member of The Fetus as a Patient society, the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and the International Society for Twin Studies.
He is a peer reviewer for several medical journals, including the American Journal of Obstetrics and Gynecology, Obstetrics and Gynecology, Journal of Maternal-Fetal and Neonatal Medicine, British Journal of Obstetrics and Gynecology, Fetal Therapy and others. He is an Editorial Board Member of the Journal of Maternal-Fetal and Neonatal Medicine and member of the Organizing Committee of the 4th World Congress of Twin Pregnancy in Madrid and of the Scientific Committee of the recent 1st World Congress on Maternal-Fetal and Neonatal Medicine in London



Dr. Eftichia Kontopoulos

Graduated Cum Laude from Semmelweis University School of Medicine. 
Subsequently, she conducted medical research at Harvard University.

She completed her residency training in Obstetrics and Gynecology and her Maternal-Fetal Medicine fellowship at Robert Wood Johnson UMDNJ.

She is a pioneer in the field of Fetal Therapy- Fetal Surgery. She described the first case of a fetoscopic removal of an oral teratoma, the first fetal bronchoscopy and the taxonomy classification of twin gestations.

Dr. Kontopoulos has extensive experience in fetal ultrasound, prenatal diagnostic techniques and fetal surgery.

Dr. Kontopoulos as Professor in Obstetrics and Gynecology and Maternal-Fetal Medicine, has always enjoyed teaching and has previously served as Maternal-Fetal Medicine fellowshipDirector.

She is the author of numerous peer-reviewed articles in leading medical journals and a frequent speaker at national and international meetings.

Member of the International Society of Twin Studies and of the International Society of Ultrasound in Obstetrics and Gynecology.

Fellow of the American College of Obstetrics and Gynecology as well as of the Society of Maternal Fetal Medicine.

Member of the Editorial Board of the Journal of Maternal-Fetal and Neonatal Medicine and a peer reviewer for the American Journal of Obstetrics and Gynecology.

Dr. Kontopoulos has been featured in the media, including the major TV news channels, as well as other National and International media.

She is well known for her personalized care and dedication to her patients. 

As pioneers and leaders in Fetal Therapy, Dr. Quintero and Dr. Kontopoulos

have a long list of clinical and academic achievements, including:


  • Diagnosis of Meckel-Gruber syndrome at 11 weeks’ gestation via transabdominal thin-gauge embryofetoscopy

  • First successful umbilical cord occlusion in the management of TRAP sequence (acardiac twins)

  • First successful fetal laryngoscopy for the management of congenital diaphragmatic hernia

  • First successful fetal cystoscopy and ablation of posterior urethral valves

  • First successful lysis of amniotic bands

  • First successful treatment of iatrogenic ruptured membranes with the Amniopatch

  • First successful fetal hydrolaparoscopy and fetal cystotomy for the treatment of fetal bladder outlet obstruction

  • First successful in utero demonstration of vesicoureteral reflux

  • First successful cardiac endoscopy in the treatment of critical congenital aortic stenosis

  • First successful fetoscopic removal of an oral teratoma

  • First successful fetal bronchoscopy in the management of extralobar pulmonary sequestration

  • First successful fetal lung biopsy for complicated type III congenital pulmonary airway malformation

  • First successful fetal eyebrow biopsy for the diagnosis of trichothyodystrophy

  • Description of the selective technique for the laser treatment of twin-twin transfusion syndrome

  • Successful treatment of selective intrauterine growth restriction using the selective laser technique

  • Successful treatment of twin-twin transfusion syndrome in monoamniotic twins

  • Successful treatment of fetal bladder obstruction using the Q-shunt

  • Successful tracheal occlusion using a modified Z-stent for the treatment of congenital diaphragmatic hernia

  • Classification of twin-twin transfusion syndrome using the Quintero Staging system

  • Successful treatment of type-II vasa previa

  • Successful devascularization of placental chorioangioma

  • Description of a gestational age-independent sonographic marker to assess fetal lung size: the
    Quantitative Lung Index (QLI)